First treatment of cancer vaccine emerges

First treatment of cancer vaccine emerges
First treatment of cancer vaccine emerges
In June of this year of tinkling of pieces of jade of sea, vaccine EGF vaccine of treatment of cancer gets permission to be listed in Cuba. This vaccine is from amynologic centre (CIM) of the Cuban molecule Research and develop, can be used for treating not to be cellule lung cancer. Clinical research verifies, this medicine unites the standard chemotherapy scheme, can even lengthen lung cancer patient's life cycle for 4- 5 months longer, and can improve the patient's body constitution and strengthen resistance. This is that the first one that is sanctioned in the world can guide the human immunity in coordination with initiating anticancer vaccine of the attack to tumour. It is a new concept of immunization therapy set up and developed in recent years that the complexity exceeds treatment vaccine of traditional vaccine. Usually, the application target of preventative vaccine is a normal crowd, but person who carries symptom or patient who has already had illness coming on does not have infected pathogenic microbe in application target of therapeutic vaccine. Traditional vaccine can activate the specific immunity to reply in the healthy human body, produce specific antibody and cell malicious T lymphocyte (CTL) ,Thus obtain and prevent ability to the immunity of this pathogen, but can't lure and grow the effective immunity to reply to the individual who has already had illness coming on. The immunity that therapeutic vaccine aims at breaking the organism is tolerated, improve the immunity of the organism to reply. Its mechanism may be to reply ability to absorption, expression, dealing with, presenting and activation immunity of the target antigen of vaccine through improving and strengthening. It can until ill individual induce the specific immunity to reply already, remove pathogen or unusual cells, make disease cure. Therapeutic vaccine is mainly applied to there is not disease treating the medicine effectively yet at presenting, for instance: Tumour, one's own immunity is infected with, transplants repelling, hypersensitivity etc. illly, chronically. Therapeutic vaccine, as a kind of new developing vaccine taking treating as purpose, in mentality of designing, prepare means with application technology reflects the pluralism and stage construction, with modern molecular biology and characteristic which the cytologic technology combines closely, its complexity far goes beyond traditional preventative vaccine. Turn on the tumour target in the new era EGF vaccine of treatment, this kind has had the target to already arouse the attention from drugmaker of countries all over the world to new medicine of properties. At present, Peru is going on to the verification of medicines, it is estimated that can be listed at the end of the year, and, already through the clinical experiment of medicines, it is estimated and put into application over the next 2~3 years in U.S.A.. In China, are taken charge of clinical research and industrialization of this medicine by one hundred Thai biological Pharmaceutcal Co., Ltd. of Beijing and produced, and will launch large-scale clinical research in China at the end of 2008 and further verify the curative effect to the person who didn't get cellule lung cancer of this medicine. The most frequently used method of tumour treatment is the chemotherapy, but the side effect of chemotherapy is great, while killing cancer cell, have eliminated normal cells too. Treat tumour through the immune system, the side effect is very small. It is mainly through injecting vaccine of tumour, kill tumour cells that the immune system treats tumour. It is the growth out of control that tumour cells are different from one of the main characteristics of normal cell, tumour cells can produce some growth factors and promote cells to grow unrestrictedly, EGF (epidermis growth factor) It is the molecule playing an important role in cells are proliferated and split up that found in recent years. EGF vaccine is exactly the method of using the specificity to be voluntarily immune, organize high EGF-EGFR (epidermis growth factor receptor) that expresses with tumour Click for the function target in the systematic signal thorough fare. After the patient inoculates this vaccine, stimulate the immune system and produce to direct against the antibody of EGF, blocked and lain between the downstream signal led by EGF-EGFR and conducted the thorough fare, thus wound tumour cells, for to treat, offer newer choice target, member of tumour. ASCO (U.S.A.'s clinical oncology) The conference has reported the clinical research progress of EGF vaccine for several years in succession. The person who didn't get cellule lung cancer that can't excise in later period is after accepting a gleam of chemotherapy, divided into two groups at random, one group inoculates EGF vaccine, another group accepts that supports the treatment best, inoculated time as the 0th, 7th, 14th, 21st, 51st day, later inoculated once per month. The result of study reveals: The patient of experimental group lengthens 4- 5 months more than the patient of control group in total life cycle, patient's body constitution is improved notably, resistance is strengthened. It is a biological medicine of high technology that vaccine is developed to develop the category. FDA report reveals, vaccine trade is fast growing, it is up to 44% to increase the variety every year, is used in the treatments of diseases such as cancer, AIDS, hepatitis B, rheumatoid and arthritis,etc. respectively. The authoritative expert predicts, the future heavy scale bomb of biotechnology - -Biological medicines will be made up of 5 kinds: Monoclonal antibody, nuclear acid, the intersection of gene therapy and medicine, soluble the intersection of protein and medicine, vaccine against justice ' Especially therapeutic vaccine) ,It is obvious therapeutic vaccine has already been paid attention to extensively. National biotechnology development outline and 863 Program that the Ministry of Science and Technology of our country prints and distributes all classify the prevention measure that great disease is relevant as the important research field, the development of medical vaccine is that the biological technical field of our country strives to be close to or exceed one of the strategy breach of the international most advanced level. So, developing therapeutic vaccine and studying will have a great theory meaning, have enormous economy and social benefit. The research and development of therapeutic vaccine has already received the world-wide extensive concern.


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