Preventing and curing myocardium infarction has new targets that is clicked

Preventing and curing myocardium infarction has new targets that is clicked
Preventing and curing myocardium infarction has new targets that is clicked
It is reported ' Reporter Wang Dan) A few days ago, bank up seminar that a researcher was led of the peak with earth to find by the intersection of Ins of animal,Academia Sinica and Li under study for action, miRNA-499 can wither and die to halt myocardium infarction through inhibiting myocardium cells, there is cardiac muscle that protect the function, this research prevented from in order to expound myocardium infarction to have illness coming on in mechanism, myocardium infarction and the diagnosis tactics are offered the new thinking. Already the 1st issue is issued in 2011 in the world-famous medical periodical " natural medical science " for this research results. It is introduced cardiac muscle ischemic myocardium the intersection of cellular capacity and supersession can lead to the fact myocardium cells wither, lose while being enough, and then myocardium infarction takes place. There is the report that reveals, the myocardium organization of infarction compares with the normal myocardium organization, miRNA (one kind has non- one that adjusts and controls the function to encode the ribonucleic acid) Expression present difference,it is play an important role in myocardium infarction not to be lasted miRNA. In national natural science fund key item and the Ministry of Science and Technology " 973" Under the subsidy of project, Li banks up peak seminar with earth to find, while the myocardium cells induced in big mouse myocardium infarction tissue and oxygen deficiency wither and die under study for action, the expression level of miRNA-499 is reduce notablied, it verifies the function of dying that miRNA-499 inhibits myocardium cells to wither to further study. This research group constructs heart -specific little mouse of miRNA-499 transgenosis, pass the finding, after inducing little mouse's myocardium infarction, the withering of little mouse of transgenosis dies myocardium cell, myocardium infarction area are obviously reduced, heart the intersection of function and every index improve notably too, it explains miRNA-499 to be can through inhibit, wither and lose to give play to the function that the cardiac muscle protects by myocardium cell. Researchers point out, the above-mentioned result of study has the signification for researching and developing and regarding small ribonucleic acid as the target and clicking the medicine curing relevant heart disease.


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