Glucocorticoid can stimulate the fat to decompose directly

Glucocorticoid can stimulate the fat to decompose directly
Glucocorticoid can stimulate the fat to decompose directly
It is reported ' Reporter Fu DongHong) Medical fat and supersession the Xu 's' permanent professor and its doctor Xu Chong of research room of department department of physiology of Peking University, mobilize the research of function to make important progress to the fat of glucocorticoid. The research has expounded glucocorticoid stimulates the fat to decompose and raise the new mechanism of the free fatty acid of blood plasma directly, raise the emergence mechanism of clinical phenomena such as the free fatty acid of blood plasma and causing insulin to resist,etc. for glucocorticoid, have offered the brand-new explanation. This research results have already secreted " member's endocrinology " learnt in U.S.A. ' Influence the factor 5.34) The network edition of the magazine is issued. It is introduced, the important hormone that since the internal renal gland cortex secreted of glucocorticoid, also one kind has clinical medicine to treat function extensively. Accept the glucocorticoid therapeutic patient or patient of the high cortisol blood disease on clinic, will raise, resist the phenomenon with insulin the density of free fatty acid of blood plasma, shown as, the diabetic using glucocorticoid to treat tolerates insulin, need to strengthen insulinogenic consumption and control blood glucose effectively. The free fatty acid of high blood plasma is the important inducement causing insulin to resist, glucocorticoid can raise the free fatty acid in the blood, but the emergence mechanism on this function is not so obvious. These decades, the mechanism that the medical textbook has thought glucocorticoid promotes the fat to mobilize, depend on " permissive action " Come to realize, namely glucocorticoid can allow and strengthen the effect that other hormone stimulate the fat to decompose, the hormone includes catecholamine hormone, thyroxine and growth hormone. Professor Xu GuoHeng's research indicates, glucocorticoid can stimulate the fat to decompose directly. Glucocorticoid, through acting on the receptor of the fat cell, activate the protein kinase A signal thorough fare in cells, reduce a kind of lipoprotein and drip the bag the albumen content, increases phosphorylation and activity of lipase, thus stimulate triglyceride to decompose and turn into the free fatty acid directly. Through this mechanism, glucocorticoid increases fatty acid to release from the fat cell into the blood, cause the free fatty acid of blood plasma to raise, resist with insulin.


|